The family Ampharetidae comprises benthic, sedentary, deposit-feeding polychaetes inhabiting self-constructed sandy or muddy tubes within marine sediments. In this study, a new species, Lysippe indica sp. nov., is described from the eastern continental shelf of the Bay of Bengal, India, at a depth of 185 m. Specimens were collected during Cruise No. 353 onboard FORV Sagar Sampada in November 2016 (17°09’69.00’’ N, 83°17’89.00’’E). Ethanol-preserved specimens were analyzed using integrative taxonomy, combining morphological and molecular approaches. Morphological observations were performed using a stereomicroscope (Labomed) and compound microscope (Nikon Eclipse Ci), supported by imaging with a Canon 70D camera and detailed illustrations using a Y-IDT camera lucida. The new species closely resembles Lysippe caeca but differs by the presence of a pair of long, thick anal cirri on the pygidium, branchiae with distinct vertical white bands, and a total of 18 thoracic chaetigers. Molecular identification based on the mitochondrial cytochrome c oxidase subunit I (COI) gene (654 bp) confirmed its distinctiveness and placement within the genus Lysippe. These findings validate Lysippe indica sp. nov. as a novel species and highlight the biodiversity of deep-sea Ampharetidae in the Bay of Bengal.